“So we are looking forward to the readout towards the end of this year for both POETYK-PsA-1 and POETYK-PsA-1 within 2024.”

In context

“2021. But this comes with significant rebating and gross net impact that will be compensated by increased volume over time. It's going to take a few quarters for that to wash out. In fact, in Q3, you saw some of this. We saw some of the pull-through delivered both versus prior year and sequentially when you exclude clinical trials. So this is a market that is going to remain highly competitive, and we're going to continue to work to increase more market share as well as paid prescriptions. But as we exit this year, we will be in a better position versus where we started the year, and we're going to work to be more competitive. Samit Hirawat: Thanks for the question, Louisa, for the arthritis part. Remember, we have been able to pull and accelerate the readout of the second study as well. So we are looking forward to the readout towards the end of this year for both POETYK-PsA-1 and POETYK-PsA-1 within 2024. Overall, as you can imagine, since a lot of data has now been generated from a safety and efficacy perspective for Sotyktu in psoriasis the readout of the program will put us in the right footing as we think about the competitor profile versus Otezla as well. So looking forward to that, we have no concerns from a safety perspective as we've said, so hopefully, the studies read out positive that will lead to a filing in 2025. Operator: The next question will come from Geoff Meacham with Citibank. Geoff Meacham: For Chris or Samit on the Milvexian program, I know you guys did talk about the use of -- the potential to upsize the trial previously. But -- what would you say is the cause for the lower event rate? Does this change the risk profile? We know that GLP-1s have an impact, for example”