“But taken together, we see this as essentially net neutral across our portfolio.”

In context

“ger that we stopped develop in multiple myeloma. But next year, in 2025, you will see a study -- a couple of studies starting in a couple of indications that we will certainly test out the theory for application of BCMA-directed bispecific in those diseases. Adam? Adam Lenkowsky: Yes. So just the question around the changes to the benefit design as it relates to IRA. So with the elimination of the coverage gap, we expect favorability with Eliquis next year due to CAR T redesign with the elimination of the coverage gap. But that's going to be offset largely by products like Revlimid and Pomalyst in the catastrophic phase, where we're now responsible for 20%. So there are pushes and pulls with IRA opportunities, including patient affordability, also with changes in the CAR T benefit design. But taken together, we see this as essentially net neutral across our portfolio. Operator: The next question will come from Matt Phipps with William Blair. Matt Phipps: Just wondering how you all view the market opportunity for the GPRC5D CAR T maybe relative to Abecma, given you've now moved the 5D program into a second-line Phase 2 trial, do you think the profile is strong enough to really challenge a BCMA CAR T? Or would it be used after a BCMA CAR T. And Chris, what type of are you going with tonight? Chris Boerner: So we'll start with Adam, and Samit, you can chime in as well. Adam Lenkowsky: Yes. So, we started the study with our GPRC5D agent will be moving that quickly into Phase 3 registrational trials. We are very encouraged with what we've seen thus far. Remember, this is going to be an important asset that is going to be used after BCMA CAR T treatment is a”