“We anticipate that, that Phase 2 data readout in the next couple of years and then start the Phase 3 program based on the doses that we have identified in that Phase 2 program.”

In context

“ve always indicated that as we think about myosin cardiac inhibitors, with the impact that it does have on the cardiac function and remodeling in general, there is an important element that we wanted to test out, which we first tested out with mavacamten in a small number of patients, which gave us an inkling into the -- through the biomarker work that we did over there through NT-proBNP as well as [indiscernible] measurement, which gives us confidence to continue with that program. We switched over to MYK-224, which was the second program that was available to us, and that's the beauty of having 2 cardiac myosin inhibitors in the programs. And -- that trial is enrolling very well. We are now extending that trial in terms of the Phase 2a study to enroll more patients to generate the data. We anticipate that, that Phase 2 data readout in the next couple of years and then start the Phase 3 program based on the doses that we have identified in that Phase 2 program. And then in the early part of next decade is when we anticipate to really have the Phase 3s reading out. We don't have a time line specifically in terms of the year -- but really excited to see what we have seen thus far and looking forward to initiation. Adam Lenkowsky: Yes. As far as the opportunity, this is a large opportunity where heat affects around 3 million people in the United States and that is expected to grow significantly over the course of the decade. In fact, the heart failure drugs, the category is valued at over $12 billion in 2022, and we expect this to almost double by 2032. So this is a significant opportunity, and we're really pleased with what we're seeing early on with MYK-224. Chris Boerner: Thanks, Adam. Well, thanks, everyone, for joining us for the call today an”