“The remaining quarters of 2025 should steadily increase, particularly in the second half of the year due to the elimination of the coverage gap.”

In context

“n and educating the U.S. market on the benefits of Opdivo Kuventeg, and we expect low single-digit growth for this product and OPDIVO taken together. With Optolag, we delivered another quarter of double-digit growth driven by demand in the U.S. where it remains a standard of care in first-line melanoma ex U.S. sales benefited from uptake in newly launched markets. Moving to cardiovascular on Slide 13. Eliquis delivered over $3 billion in fourth quarter sales. U.S. sales grew 19%, benefiting primarily from continued strong demand and the typical inventory build. Importantly, as you think about the impact to Eliquis from Medicare Part D redesign, Q1 U.S. sales growth will be tempered sequentially due to the implementation of the 10% manufacturer responsibility in the initial coverage phase. The remaining quarters of 2025 should steadily increase, particularly in the second half of the year due to the elimination of the coverage gap. Turning to KEmZyOs, sales in the fourth quarter more than doubled, benefiting from higher demand and a large inventory build. -- as a standard of care and obstructive HCM, KIMZYOs continued to show strong momentum as evidenced by the approximate 1,300 new patients added to commercial drug in the fourth quarter. Additionally, we recently received a label update for KEMZIOS in Europe to ease the echo monitoring requirements in the maintenance setting for obstructive HCM. Importantly, we are pleased to announce today that we have a PDUFA date in April for a similar easing of the REMS echo monitoring requirements in the U.S. Let's turn to hematology on Slide 14. Rebase delivered more than 70% growth, reflecting solid uptake across first and second line MDS-associated anemia patients. Sales in”