“In fact, what we're going to see in Q1 is going to be the lowest quarter of sales for Eliquis mid-single-digit sequential growth from Q4 to Q1 globally.”

In context

“e the business is. Chuck Triano: Thanks, Chris. Alison, can we go to our next question. Operator: Next question will come from Luisa Hector of Berenberg. Luisa Hector: I just wanted to take your assumption for Part D redesign, if you can quantify it in 2025. And then just an update on cendakimab, I don't see it on the slides, but any updates on the filing plans there. Christopher Boerner: Thanks for the question, Luisa. I'll have Adam take both of those questions. Adam Lenkowsky: Thanks, Luisa. As relates to Part D redesign, there are pushes and pulls. Overall, we're going to see favorability with Eliquis due to the elimination of the coverage gap and with that, we're not going to see the historical dynamics with Eliquis, where first half sales have been higher than the second half sales. In fact, what we're going to see in Q1 is going to be the lowest quarter of sales for Eliquis mid-single-digit sequential growth from Q4 to Q1 globally. And we'll see second half sales be higher than first half sales. But for the full year, we expect strong year-on-year growth for Eliquis. Now when you look at products like REVLIMID, POMALYST, ORENCIA and CAMZYOS, for example, that's going to offset the Eliquis favorability as we see increasing gross to net pressure starting in as patients enter the catastrophic phase. And as you know, we're responsible for 20% in the catastrophic phase and 10% in the initial coverage phase. But as we've said previously, we project it to be roughly net neutral across our portfolio this year. As it relates to cendakimab, given the data that we have seen, we've made the decision not to commercialize cendakimab. We're going to continue to prioritize investments and opportunities where we have a competitive a”