“So we previously would have assumed we had a time line as we model the impact of IRA. Now with this change, we would not expect Venclexta to be negotiated.”

In context

“ond question on aesthetics. I know you talked about pushes and pulls, a question I've asked in the past. The impact from the GLP-1s on BOTOX and dermal fillers, what's the latest? Is it helping sales, hurting sales or net neutral? Robert A. Michael: Tim, it's Rob. I'll take your first question. Obviously, as we go through these negotiations, we don't publicly comment for obvious reasons. And as you know, the price will be public in November, and we'll comment as appropriate at that time. But as it relates to the IRA, I do think one important notable change as part of the One Big Beautiful Bill Act is the expansion of the IRA orphan drug exemption, Drugs with more than one orphan designation are now exempt from IRA negotiations, which will be a benefit to our own cancer therapy, Venclexta. So we previously would have assumed we had a time line as we model the impact of IRA. Now with this change, we would not expect Venclexta to be negotiated. And that's an example of a good policy change where innovation is being rewarded and not penalized. But as it relates to the current negotiations, we'll provide commentary once those prices are public. Jeffrey Ryan Stewart: Yes. And regarding the GLP-1s, I would say, overall, what we see after numerous discussions and working with our clinics, Tim, is that it's really a net neutral. I mean, if anything, if you look at it, I mean, the filler market, where, in some cases, people are interested and as they lose their facial muscle and fat, you think that would be a tailwind for the dermal filler market. And we've seen that, that's just been more afflicted clearly by macro issues and some sentiment issues. So net-net, we see it as really a neutral effect. Operator: Your next question comes fr”