“We have I would say a small or moderate impact on GLP sales or just probably lower rates of abandonment than what we'd see at higher out-of-pocket costs.”

In context

“considerable advantages in efficacy for glycemia and white. But I'm reminded of the stickiness of the [indiscernible] in the prior period. To what extent do you think managed market is going to preclude your ability to penetrate that segment with oral GLP-1s just on the basis of generic DPP-4s? thank you. Joe Fletcher: Thanks, Andrew for the wide-ranging question on diabetes. I'll hand over to Mike first to talk about your question regarding potential impact of the IRA on access for GLP-1. And then the second question around how oral GLP might fit in given the stickiness of some of the older diabetes medications. Mike? Mike Mason: Yes. Good questions. On the IRA side of it, it will benefit patients who live with diabetes who use GLPs and are Medicare Part D the outpace cost will go down. We have I would say a small or moderate impact on GLP sales or just probably lower rates of abandonment than what we'd see at higher out-of-pocket costs. As it comes to the oral DPP4 the perceptions of oral DPP-4 have really declined over the last five years and really being replaced by ST2s and GLP lose. So I don't see much of an impact of DPP-4s going off path in the US or other markets. Joe Fletcher: Thanks, Mike. And Lois, I think we have one final question in the queue. So let's go to the last question. Operator: Thank you. And that's from Robyn Karnauskas from Truist Securities. Please go ahead. Robyn Karnauskas: Great. Thanks for taking my question. I was just thinking more about some of the launches that are coming up but I know the maybe a little bit out. But for Mirikizumab and I always get this wrong, sorry. But for UC, can you just talk a little bit about given how much promotion there's been for [indiscernible] as you move in”