“We expect to produce at least 1.8x the number of salable incretin doses in the second half of 2025 compared to the second half of 2024.”

In context

“eign exchange rates. We will continue to invest to support our newest launches and to develop new medicines. Given our updated expectations for revenue growth, we now expect non-GAAP performance margin to be between 43% and 45.5% as a percentage of revenue. The potential effect of tariffs remains dynamic, and we will continue to update our estimate as the situation changes. We expect the 2025 impact of currently announced tariffs to be modest, and this has been factored into our 2025 guidance range. At the bottom line, we have increased our outlook for non-GAAP earnings per share and expect EPS of $21.75 to $23. As Dave mentioned earlier, we exceeded our incretin salable doses production in the first half of the year and expect to bring more capacity online during the second half of 2025. We expect to produce at least 1.8x the number of salable incretin doses in the second half of 2025 compared to the second half of 2024. Now I will turn the call over to Dan to highlight our progress on R&D. A - Daniel M. Skovronsky: Thanks, Lucas. We've made quite a bit of progress since our last earnings call. During just the past 2 weeks, we shared 3 Phase III readouts from some of our most important molecules. I'll start with these. Last week, we announced results from the tirzepatide SURPASS-CVOT trial, where tirzepatide demonstrated cardiovascular protection in a landmark head-to-head trial which was the first ever cardiovascular outcomes trial comparing 2 incretin therapies in people with type 2 diabetes and cardiovascular disease. It included over 13,000 participants across 30 countries and it is the largest and longest study of tirzepatide to date. As shown on Slide 13, tirzepatide achieved the primary objective o”