“We also announced plans to initiate a new Phase III trial in people with knee osteoarthritis pain in overweight or obesity starting later this year.”

In context

“o move quickly towards our first regulatory submissions yet this year. We expect results from 4 additional orforglipron Phase III trials over the next 5 months, 3 trials in people with diabetes from our ACHIEVE program. and 1 additional trial from the ATTAIN program in people with diabetes and obesity. ATTAIN-1 and ATTAIN-2 will support global submissions for chronic weight management, which we expect in Q4. In addition to the ongoing Phase III trials for orforglipron in diabetes, obesity, weight maintenance and obstructive sleep apnea, we initiated a new program for orforglipron this quarter, ATTAIN-Hypertension, focused on reducing systolic blood pressure at 36 weeks as the primary endpoint. This is the first study of orforglipron that includes patients with a baseline BMI as low as 25. We also announced plans to initiate a new Phase III trial in people with knee osteoarthritis pain in overweight or obesity starting later this year. Moving to pirtobrutinib. We announced positive results from the BRUIN CLL-314 Phase III trial of pirtobrutinib compared to ibrutinib in people with CLL/SLL. This trial included treatment-naive patients as well as patients previously treated but not with the BTK inhibitor. Pirtobrutinib met the primary endpoint of response rate non-inferiority compared to ibrutinib and had a nominal p-value for superiority that was less than 0.05. While progression-free survival data were immature, there was a positive trend in favor of pirtobrutinib. Additional testing for progression-free survival is planned as part of a future analysis. Of note, the subpopulation of treatment-naive patients had a particularly pronounced progression-free survival trend in favor of pirtobrutinib. This subpopulation had th”