“We plan to discuss the results with regulators and initiate Phase 3 trials in multiple tumors this year.”

In context

“and KEYLYNK-012 studying KEYTRUDA in combination with Lynparza in Stage III disease. These trials are all part of our broader effort to treat earlier stages of cancers and further improve patient outcomes across tumor types, such as melanoma. Together with Moderna, we announced positive Phase 2 results for V940/mRNA-4157, in combination with KEYTRUDA for the adjuvant treatment of Stage III and IV melanoma in patients with high risk of recurrence following complete resection. The combination demonstrated a statistically significant and clinically meaningful improvement in recurrence free survival versus KEYTRUDA alone. This investigational personalized neoantigen therapy utilizes mRNA technology and is specifically tailored to target the unique mutational signature of each patient’s tumor. We plan to discuss the results with regulators and initiate Phase 3 trials in multiple tumors this year. Detailed results will be presented at an upcoming medical meeting. We also announced positive results from the Phase 3 KEYNOTE-966 trial evaluating KEYTRUDA in combination with chemotherapy. This trial demonstrated an improvement in overall survival for the first-line treatment of patients with advanced or unresectable biliary tract cancer. In addition, we announced positive topline results from the Phase 3 KEYNOTE-859 trial evaluating KEYTRUDA in combination with chemotherapy for the first-line treatment of patients with HER2-negative locally advanced unresectable or metastatic gastric or gastro-esophageal junction adenocarcinoma. In November, we announced the acquisition of Imago Biosciences, which closed last month. Imago’s lead candidate, bomedemstat, is a potentially first-in-class o”