“We also anticipate starting an additional first-line study in combination with vepdegestrant, the ER degrader we are codeveloping with Arvinas.”

In context

“peak about our 2025 priorities. Last year, we had a significant emphasis on improving our commercial effectiveness. In 2025, the emphasis will move to improving R&D productivity, while maintaining focus on margin expansion, commercial excellence and shareholder lending capital allocation. Let me start with R&D. Across our pipeline, we believe we have a strong year of catalysts ahead of us and expect our new R&D organization to achieve multiple key milestones, including the possibility of at least four regulatory decisions, up to nine potential Phase 3 readouts and 13 potential pivotal program starts. For example, with atirmociclib, our next generation highly selective CDK4 inhibitor candidate, yesterday, we dosed our first patient in a Phase 3 study in first-line metastatic breast cancer. We also anticipate starting an additional first-line study in combination with vepdegestrant, the ER degrader we are codeveloping with Arvinas. Our ADC sigvotatug vedotin continues its Phase 3 study in second-line non-small cell and cancer. And this year, we expect to start a Phase 3 study in first-line non-small cell lung cancer. Our PDL1 ADC candida, a potential first-in-class PD-L1 targeting vedotin ADC, is expected to begin 2 Phase 3 studies this year, one in first-line metastatic head and neck squamous cell carcinoma and one in second-line-plus non-small cell lung cancer where the unmet need is significant. We have a robust clinical development program aimed at expanding are indications in multiple myeloma, and this year, we anticipate the readout of a Phase 3 study in double class exposed relapsed refractory multiple myeloma, that, if successful and approved, will triple the addressable population versus the currently appro”