“the olpasiran Phase III program, which as you heard is -- it has an event-driven outcome, expected a readout in the second half of next year.”

In context

“nergies and the like. We've learned a lot from Repatha already. We have a leading capability in population genetics and epidemiology. And now the broad use of Repatha in secondary prevention is a fantastic setup for VESALIUS-CV. As you know, this is a Phase III large cardiovascular outcome study of more than 12,000 patients, placebo-controlled, patients at high cardiovascular risk without prior MI or stroke. This is ongoing. We have an event-driven readout expected in the second half of this year. This will be a large and valuable data set for us to mine to understand the further improvement of cardiovascular outcomes for patients as it relates to LDL-C, but also for other parameters. We have already harvested so many insights from Repatha and carried that into the design and execution of the olpasiran Phase III program, which as you heard is -- it has an event-driven outcome, expected a readout in the second half of next year. So very valuable data set that will, no doubt, prompt significant further insights. Murdo Gordon: Thanks, Jay. The synergies here are significant and substantial given the leadership presence we have in LDL lowering and being able to apply that to Lp(a) lowering with olpasiran obviously is successful in the readout of our Phase III trial. I do think there's going to be some differences, though, given that Lp(a) cannot be modified by lifestyle, diet and exercise. There are no other generically available or branded available products that can lower Lp(a). We do think that the intentionality and the speed to move to a pharmacotherapeutic for Lp(a) lowering will be different than it has been for LDL. But nonetheless, we're clearly engaged with all of the different stakeholders in the lipid lo”