“it does follow the pattern we see in some other products in our portfolio where that first quarter this year will be a little bit lower than the other 3 quarters, mostly a function of people having their insurance reverified and/or purchasing patterns in the market.”

In context

“d steady momentum. And so Japan will be a very good source of growth for TEPEZZA internationally. As I mentioned, we've got 7 other markets that we'll be launching in, hopefully, this year, pending regulatory approvals. And we do see that international catalyst -- that international growth as a catalyst for the overall brand. And it's obviously one of the things that drove the acquisition, the ability for Amgen's global footprint to bring these medicines to more patients. In the U.S., we continue to focus on broadening the prescriber base for TEPEZZA. So helping general ophthalmology and endocrinology diagnose, not just the Gravis disease but also the thyroid eye disease and then find a site of care for patients to receive as a treatment. Just one overarching comment I'll make on TEPEZZA, it does follow the pattern we see in some other products in our portfolio where that first quarter this year will be a little bit lower than the other 3 quarters, mostly a function of people having their insurance reverified and/or purchasing patterns in the market. So just something to watch out for. But long term, TEPEZZA growth is looking very good given the international approvals and the momentum that we plan to generate in the U.S. Operator: Our next question comes from James Shin from Deutsche Bank. James Shin: Any color on the indication for the MARITIME trials that will start in the first half '25? And can you say anything on whether or not MARITIME will have head-to-head against incumbents such as tirzepatide or sema at this point? James Bradner: Yes. Thank you, James. The MARITIME Phase III program has a focus on chronic weight management, on cardiovascular disease, kidney disease, type 2 diabetes, sleep apnea, heart failure and possibly additional indications. As our discussions are at a rather mature state with the federal regulators, it”